4 May 1493-Pope Alexander VI divides the New World between Spain and Portugal along the Line of Demarcation.

Pope Alexander VI published a bull, 'Inter caetera', which granted to Spain (the Crowns of Castile and Aragon) all lands to the "west and south" of a pole-to-pole line 100 leagues west and south of any of the islands of the Azores or the Cape Verde islands.

4 May 1519 - Death of Lorenzo II de' Medici, Duke of Urbino.
He was the son of Piero di Lorenzo de' Medici and Alfonsina Orsini,husband of Madeleine de la Tour, daughter of the Count of Auvergne, and father of Catherine de' Medici,Queen of France